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KMID : 0370220070510020140
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Yakhak Hoeji
2007 Volume.51 No. 2 p.140 ~ p.144
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Antilipoperoxidant Activity of Antraquinone and Stilbene from Polygonum cuspidatum
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Joo Si-Mong
Yang Ki-Sook
Lee Min-Won
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Abstract
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Polygonum cuspidatum has been used as treatments of dermatitis, gonorrhea, inflammation, and hyperlipidaemia in traditional medicine. We examined liver protective effect on CCl[4] inducing hepatotoxicity and anti-oxidative activity by TBA method. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin 8-O-β-D-glucopyranoside (compound 1), and trans-resveratrol 3-O-β-D-glucopyranoside (compound 2). Compounds 1 and 2 enhanced the inhibition of anti-lipid peroxidative effects in liver homogenate. In chemical parameters obtained from serum analysis, compounds 1 and 2 also revealed significant decrease in hepatotoxicity. These results suggested that the antraquinone and stilbene which were isolated from Polygonum cuspidatum might be used as therapeutic agent of hepatitis.
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KEYWORD
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Polygonum cuspidatum, emodin 8-O-β-D -glucopyranoside, trans-resveratrol 3-O-β-D -glucopyranoside, hepatotoxicity
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